MOTS-c 10 mg

MOTS-c for research: identity and specifications

MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c, CAS 1627580-64-6) is a synthetic 16-amino-acid peptide corresponding to a mitochondrial DNA-derived peptide, studied in metabolic regulation. Supplied as a 10 mg vial of lyophilized powder, with no fillers, carriers or excipients, at ≥99% purity by HPLC, with the lot-specific value reported on the certificate of analysis.

Scientific background

In experimental models, MOTS-c is investigated for its activation of AMP-activated protein kinase (AMPK), its modulation of the folate-methionine cycle and the accumulation of AICAR in cultured cells. In vitro studies also examine glucose uptake in skeletal muscle cells and the translocation of the peptide to the nucleus under metabolic stress.

Preclinical literature uses MOTS-c in rodent models of insulin sensitivity, diet-induced obesity and aging, always under controlled bench conditions and without extrapolating results to human or veterinary use.

• AMPK activation and metabolic stress response in cell culture
• Folate-methionine cycle and AICAR accumulation in in vitro assays
• Glucose uptake in skeletal muscle cells
• Insulin sensitivity and metabolism in rodent models

Technical specifications

Analytical quality and chain of custody

Every lot of MOTS-c is synthesized in registered facilities, with independent analytical verification by third-party laboratories and full chain-of-custody documentation. The certificate of analysis (COA) for each lot can be reviewed before purchase, recording HPLC purity and the other quality-control parameters used to release the material.

Reconstitution and laboratory handling

As a bench procedure, the lyophilized vial is reconstituted with a known volume of a suitable solvent, added along the inner wall of the vial, followed by gentle swirling until fully dissolved, without vigorous shaking. The reconstituted solution should be kept refrigerated and protected from light, and used in controlled assays within the stability period validated by the laboratory. Handling must be performed only by qualified personnel, in a bench environment suitable for in vitro experimentation, with lot number and storage conditions documented according to good laboratory practice.

Frequently asked questions

What is the purity of the MOTS-c supplied?

≥99% by HPLC, with the lot-specific value reported on the certificate of analysis (COA).

Are MOTS-c and the mitochondrial DNA-derived peptide the same compound?

Yes, MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) is the name of the 16-amino-acid mitochondrial peptide, identified by CAS number 1627580-64-6 and PubChem CID 146675088.

How should the compound be stored?

At -20 °C, protected from light and moisture, as a lyophilized powder until reconstitution.

Does the certificate of analysis come with the lot?

Yes, every lot has a matching COA that can be verified before purchase using the button on this page.

Who can purchase MOTS-c?

Sales are restricted to qualified researchers and institutions, for laboratory use only, as detailed in the research-use-only notice on this page.

See the peptide reference guide, the page on how every lot is tested by HPLC and COA and the molecular structure in the PubChem database.

Research use only (RUO). This material is supplied for in vitro laboratory research only. It is not a drug, dietary supplement or cosmetic, and it is not intended for human or veterinary use, or for the diagnosis or treatment of any condition. Sales are restricted to researchers and institutions.