GHK-Cu 50 mg

GHK-Cu for research: identity and specifications

GHK-Cu (copper tripeptide-1, prezatide copper) is the copper(II) complex of the naturally occurring tripeptide glycyl-L-histidyl-L-lysine (GHK), studied as a copper-binding peptide in extracellular matrix research (CAS 89030-95-5). Supplied as a 50 mg vial, lyophilized powder, with no fillers, carriers or excipients, at ≥98% purity by HPLC, synthesized and purified under analytical controls documented for every lot.

Scientific background

The GHK tripeptide binds copper(II) with high affinity through its histidine and lysine side chains and its amino terminus, forming a stable complex that is used as a model of copper transport and delivery to cells. In in vitro experiments, GHK-Cu is investigated in fibroblast culture for its interaction with collagen and other extracellular matrix components, including expression of matrix proteins and of the metalloproteinases and inhibitors that regulate matrix turnover.

Preclinical literature also uses the complex in cell-based and rodent models to study copper-dependent enzymes, antioxidant and inflammatory signaling pathways and gene-expression changes associated with tissue remodeling, always under controlled bench conditions and without extrapolating results to human or veterinary use.

• Copper(II) binding and transfer in model systems
• Collagen and extracellular matrix protein expression in fibroblast cultures
• Matrix metalloproteinase and inhibitor balance in in vitro assays
• Copper-dependent enzyme activity and oxidative stress markers in experimental models

Technical specifications

Analytical quality and chain of custody

Every lot of GHK-Cu is synthesized in registered facilities, with independent analytical verification by third-party laboratories and full chain-of-custody documentation. The certificate of analysis (COA) for each lot can be reviewed before purchase, recording HPLC purity and the other quality-control parameters used to release the material.

Reconstitution and laboratory handling

As a bench procedure, the lyophilized vial is reconstituted with a known volume of a suitable solvent, added along the inner wall of the vial, followed by gentle swirling until fully dissolved, without vigorous shaking. The reconstituted solution should be kept refrigerated and protected from light, and used in controlled assays within the stability period validated by the laboratory. Handling must be performed only by qualified personnel, in a bench environment suitable for in vitro experimentation, with lot number and storage conditions documented according to good laboratory practice.

Frequently asked questions

What is the purity of the GHK-Cu supplied?

≥98% by HPLC, with the lot-specific value reported on the certificate of analysis (COA).

Are GHK-Cu, copper tripeptide-1 and prezatide copper the same compound?

Yes, they are synonyms for the copper(II) complex of glycyl-L-histidyl-L-lysine, identified by PubChem CID 71587328 and CAS 89030-95-5.

How should the compound be stored?

At -20 °C, protected from light and moisture, as a lyophilized powder until reconstitution.

Does the certificate of analysis come with the lot?

Yes, every lot has a matching COA that can be verified before purchase using the button on this page.

Who can purchase GHK-Cu?

Sales are restricted to qualified researchers and institutions, for laboratory use only, as detailed in the research-use-only notice on this page.

See the peptide reference guide, the page on how every lot is tested by HPLC and COA and the molecular structure of GHK-Cu in the PubChem database.

Research use only (RUO). This material is supplied for in vitro laboratory research only. It is not a drug, dietary supplement or cosmetic, and it is not intended for human or veterinary use, or for the diagnosis or treatment of any condition. Sales are restricted to researchers and institutions.