IGF1-LR3 1 mg

IGF-1 LR3 for research: identity and specifications

IGF-1 LR3 (long R3 IGF-I) is a synthetic 83-amino-acid analog of human insulin-like growth factor 1 (IGF-1) with an arginine substituted for glutamate at position 3 and a 13-residue N-terminal extension (CAS 946870-92-4). Supplied as a 1 mg vial, lyophilized powder, with no fillers, carriers or excipients, with HPLC purity reported lot by lot on the certificate of analysis.

Scientific background

The Arg3 substitution and the N-terminal extension greatly reduce binding to IGF-binding proteins (IGFBPs), so more of the peptide remains available to the IGF-1 receptor in culture. For this reason it is widely used as a defined, potent IGF-1 receptor agonist in cell-based assays.

Preclinical literature uses IGF-1 LR3 in studies of PI3K/Akt and MAPK signaling, cell proliferation and survival in culture, and in comparative work on IGF-1 analogs, always under controlled bench conditions and without extrapolating results to human or veterinary use.

• IGF-1 receptor activation and PI3K/Akt signaling in cell models
• Cell proliferation and survival assays in serum-free culture
• Interaction with IGF-binding proteins compared with native IGF-1
• Comparative studies of IGF-1 analogs

Technical specifications

Analytical quality and chain of custody

Every lot of IGF-1 LR3 is synthesized in registered facilities, with independent analytical verification by third-party laboratories and full chain-of-custody documentation. The certificate of analysis (COA) for each lot can be reviewed before purchase, recording HPLC purity and the other quality-control parameters used to release the material.

Reconstitution and laboratory handling

As a bench procedure, the lyophilized vial is reconstituted with a known volume of a suitable solvent, added along the inner wall of the vial, followed by gentle swirling until fully dissolved, without vigorous shaking. The reconstituted solution should be kept refrigerated and protected from light, and used in controlled assays within the stability period validated by the laboratory. Handling must be performed only by qualified personnel, in a bench environment suitable for in vitro experimentation, with lot number and storage conditions documented according to good laboratory practice.

Frequently asked questions

What is the purity of the IGF-1 LR3 supplied?

HPLC purity is determined for every lot and reported on the certificate of analysis (COA).

Are IGF-1 LR3 and long R3 IGF-I the same compound?

Yes, both names refer to the 83-amino-acid IGF-1 analog with the Arg3 substitution and the N-terminal extension. It is distinct from native IGF-1 (70 amino acids).

How should the compound be stored?

At -20 °C, protected from light and moisture, as a lyophilized powder until reconstitution.

Does the certificate of analysis come with the lot?

Yes, every lot has a matching COA that can be verified before purchase using the button on this page.

Who can purchase IGF-1 LR3?

Sales are restricted to qualified researchers and institutions, for laboratory use only, as detailed in the research-use-only notice on this page.

See the peptide reference guide, the page on how every lot is tested by HPLC and COA.

Research use only (RUO). This material is supplied for in vitro laboratory research only. It is not a drug, dietary supplement or cosmetic, and it is not intended for human or veterinary use, or for the diagnosis or treatment of any condition. Sales are restricted to researchers and institutions.