CJC-1295 with DAC 5 mg

CJC-1295 w/ DAC for research: identity and specifications

CJC-1295 with DAC is a synthetic analog of growth hormone-releasing hormone (GHRH) coupled to a drug affinity complex (DAC), a chemical group that enables binding to serum albumin and extends the half-life of the molecule in experimental models. Made by solid-phase peptide synthesis and purified by HPLC, it is supplied as a 5 mg vial, lyophilized powder, with no fillers, carriers or excipients, at ≥98% purity by HPLC and the lot-specific value reported on the certificate of analysis.

Scientific background

In experimental models, CJC-1295 with DAC is studied for activation of the GHRH receptor on pituitary somatotroph cells and for signaling of the somatotropic axis, with particular interest in how albumin binding prolongs the persistence of the peptide in pharmacokinetic studies of extended-stability peptides.

Preclinical literature compares it with GHRH analogs that lack the DAC moiety in cell culture and animal models, always under controlled bench conditions and without extrapolating results to human or veterinary use.

• GHRH receptor binding in pituitary cell models
• Signaling of the somatotropic axis in experimental systems
• Albumin-binding drug affinity complex and peptide half-life
• Pharmacokinetic comparisons with analogs lacking DAC

Technical specifications

Analytical quality and chain of custody

Every lot of CJC-1295 w/ DAC is synthesized in registered facilities, with independent analytical verification by third-party laboratories and full chain-of-custody documentation. The certificate of analysis (COA) for each lot can be reviewed before purchase, recording HPLC purity and the other quality-control parameters used to release the material.

Reconstitution and laboratory handling

As a bench procedure, the lyophilized vial is reconstituted with a known volume of a suitable solvent, added along the inner wall of the vial, followed by gentle swirling until fully dissolved, without vigorous shaking. The reconstituted solution should be kept refrigerated and protected from light, and used in controlled assays within the stability period validated by the laboratory. Handling must be performed only by qualified personnel, in a bench environment suitable for in vitro experimentation, with lot number and storage conditions documented according to good laboratory practice.

Frequently asked questions

What is the purity of the CJC-1295 w/ DAC supplied?

≥98% by HPLC, with the lot-specific value reported on the certificate of analysis (COA).

How does CJC-1295 with DAC differ from the version without DAC?

The DAC version carries a drug affinity complex that allows albumin binding and a longer half-life in experimental models. The version without DAC (modified GRF 1-29) lacks this group and has a different profile.

How should the compound be stored?

At -20 °C, protected from light and moisture, as a lyophilized powder until reconstitution.

Does the certificate of analysis come with the lot?

Yes, every lot has a matching COA that can be verified before purchase using the button on this page.

Who can purchase CJC-1295 w/ DAC?

Sales are restricted to qualified researchers and institutions, for laboratory use only, as detailed in the research-use-only notice on this page.

See the peptide reference guide, the page on how every lot is tested by HPLC and COA, and the molecular structure in the PubChem database.

Research use only (RUO). This material is supplied for in vitro laboratory research only. It is not a drug, dietary supplement or cosmetic, and it is not intended for human or veterinary use, or for the diagnosis or treatment of any condition. Sales are restricted to researchers and institutions.