Epithalon 10 mg

Epithalon for research: identity and specifications

Epithalon (also spelled Epitalon; EPI) is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly (CAS 307297-39-8), an analog of the peptide Epitalamin, originally described from pineal gland extracts. Supplied as a 10 mg vial, lyophilized powder, with no fillers, carriers or excipients, at ≥98% purity by HPLC, made by solid-phase peptide synthesis (SPPS) and purified under analytical controls documented for every lot.

Scientific background

In cell models, Epithalon is investigated for its effects on telomerase activity and on the expression of genes linked to telomere maintenance, in fibroblast and other cell-line culture assays. Comparative studies with other bioregulator peptides explore peptide signaling pathways and cellular regulatory mechanisms related to replicative senescence.

Preclinical literature in rodents also examines parameters tied to circadian rhythm and pineal gland function, including melatonin secretion, along with oxidative stress markers, always under controlled bench conditions and without extrapolating results to human or veterinary use.

• Telomerase activity in cell culture assays
• Gene expression linked to telomere maintenance
• Replicative senescence in cell models
• Pineal function and circadian rhythm in rodent models

Technical specifications

Analytical quality and chain of custody

Every lot of Epithalon is synthesized in registered facilities, with independent analytical verification by third-party laboratories and full chain-of-custody documentation. The certificate of analysis (COA) for each lot can be reviewed before purchase, recording HPLC purity and the other quality-control parameters used to release the material.

Reconstitution and laboratory handling

As a bench procedure, the lyophilized vial is reconstituted with a known volume of a suitable solvent, added along the inner wall of the vial, followed by gentle swirling until fully dissolved, without vigorous shaking. The reconstituted solution should be kept refrigerated and protected from light, and used in controlled assays within the stability period validated by the laboratory. Handling must be performed only by qualified personnel, in a bench environment suitable for in vitro experimentation, with lot number and storage conditions documented according to good laboratory practice.

Frequently asked questions

What is the purity of the Epithalon supplied?

≥98% by HPLC, with the lot-specific value reported on the certificate of analysis (COA).

Are Epithalon, Epitalon and EPI the same compound?

Yes, they are spellings and abbreviations of the same tetrapeptide (Ala-Glu-Asp-Gly), identified by PubChem CID 219042 and CAS 307297-39-8. Epithalon is the synthetic analog of Epitalamin.

How should the compound be stored?

At -20 °C, protected from light and moisture, as a lyophilized powder until reconstitution.

Does the certificate of analysis come with the lot?

Yes, every lot has a matching COA that can be verified before purchase using the button on this page.

Who can purchase Epithalon?

Sales are restricted to qualified researchers and institutions, for laboratory use only, as detailed in the research-use-only notice on this page.

See the peptide reference guide, the page on how every lot is tested by HPLC and COA and the molecular structure in the PubChem database.

Research use only (RUO). This material is supplied for in vitro laboratory research only. It is not a drug, dietary supplement or cosmetic, and it is not intended for human or veterinary use, or for the diagnosis or treatment of any condition. Sales are restricted to researchers and institutions.