Cagrilintide 5 mg

Cagrilintide for research: identity and specifications

Cagrilintide (CAS 1415456-99-3) is an acylated peptide analog of amylin, a hormone co-secreted with insulin by pancreatic beta cells, studied in laboratory research on amylin and calcitonin receptor pharmacology. Supplied as a 5 mg vial, lyophilized powder, with no fillers, carriers or excipients, at ≥98% purity by HPLC, with the lot-specific value reported on the certificate of analysis.

Scientific background

Acylation with a fatty diacid supports albumin binding and prolongs the analog’s persistence in experimental systems compared with native amylin. In assays using cells that express the calcitonin receptor together with receptor activity-modifying proteins (RAMPs), which form the amylin receptors, the compound is investigated for binding affinity and cyclic AMP (cAMP) generation.

Preclinical literature uses amylin analogs in rodent models of carbohydrate metabolism and neuroendocrine signaling, as well as in comparative studies with GLP-1 receptor agonists, always under controlled bench conditions and without extrapolating results to human or veterinary use.

• Binding to amylin and calcitonin receptors in cell-based assays
• cAMP signaling through receptor-RAMP complexes
• Structure-activity relationship of long-acting acylated peptides
• Comparative preclinical studies with GLP-1 receptor agonists

Technical specifications

Analytical quality and chain of custody

Every lot of cagrilintide is synthesized in registered facilities, with independent analytical verification by third-party laboratories and full chain-of-custody documentation. The certificate of analysis (COA) for each lot can be reviewed before purchase, recording HPLC purity and the other quality-control parameters used to release the material.

Reconstitution and laboratory handling

As a bench procedure, the lyophilized vial is reconstituted with a known volume of a suitable solvent, added along the inner wall of the vial, followed by gentle swirling until fully dissolved, without vigorous shaking. The reconstituted solution should be kept refrigerated and protected from light, and used in controlled assays within the stability period validated by the laboratory. Handling must be performed only by qualified personnel, in a bench environment suitable for in vitro experimentation, with lot number and storage conditions documented according to good laboratory practice.

Frequently asked questions

What is the purity of the cagrilintide supplied?

≥98% by HPLC, with the lot-specific value reported on the certificate of analysis (COA).

What identifies cagrilintide?

It is an acylated amylin analog (INN cagrilintide) identified by PubChem CID 171397054, CAS 1415456-99-3 and molecular formula C194H312N54O59S2.

How should the compound be stored?

At -20 °C, protected from light and moisture, as a lyophilized powder until reconstitution.

Does the certificate of analysis come with the lot?

Yes, every lot has a matching COA that can be verified before purchase using the button on this page.

Who can purchase cagrilintide?

Sales are restricted to qualified researchers and institutions, for laboratory use only, as detailed in the research-use-only notice on this page.

See the peptide reference guide, the page on how every lot is tested by HPLC and COA and the molecular structure in the PubChem database.

Research use only (RUO). This material is supplied for in vitro laboratory research only. It is not a drug, dietary supplement or cosmetic, and it is not intended for human or veterinary use, or for the diagnosis or treatment of any condition. Sales are restricted to researchers and institutions.