PT-141 10 mg

PT-141 for research: identity and specifications

PT-141 (bremelanotide) is a synthetic cyclic heptapeptide, an analog of α-melanocyte-stimulating hormone (α-MSH), with the sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH (CAS 189691-06-3). Supplied as a 10 mg vial, lyophilized powder, with no fillers, carriers or excipients, at ≥98% purity by HPLC, made by SPPS and purified under analytical controls documented for every lot.

Scientific background

The cyclic structure, closed by a lactam bridge between the Asp and Lys side chains, and the norleucine and D-phenylalanine substitutions increase stability against proteases. In experimental models, PT-141 is used to investigate binding to the melanocortin receptors MC3R and MC4R and downstream cAMP signaling in cell lines and hypothalamic models.

Structurally, PT-141 is related to Melanotan II, differing in its C-terminus (free acid instead of amide). Preclinical literature uses it in melanocortin receptor pharmacology and structure-activity studies, always under controlled bench conditions and without extrapolating results to human or veterinary use.

• Binding to melanocortin receptors MC3R and MC4R
• cAMP signaling in cell and hypothalamic models
• Central neuroendocrine pathways in experimental models
• Structure-activity relationships of cyclic α-MSH analogs

Technical specifications

Analytical quality and chain of custody

Every lot of PT-141 is synthesized in registered facilities, with independent analytical verification by third-party laboratories and full chain-of-custody documentation. The certificate of analysis (COA) for each lot can be reviewed before purchase, recording HPLC purity and the other quality-control parameters used to release the material.

Reconstitution and laboratory handling

As a bench procedure, the lyophilized vial is reconstituted with a known volume of a suitable solvent, added along the inner wall of the vial, followed by gentle swirling until fully dissolved, without vigorous shaking. The reconstituted solution should be kept refrigerated and protected from light, and used in controlled assays within the stability period validated by the laboratory. Handling must be performed only by qualified personnel, in a bench environment suitable for in vitro experimentation, with lot number and storage conditions documented according to good laboratory practice.

Frequently asked questions

What is the purity of the PT-141 supplied?

≥98% by HPLC, with the lot-specific value reported on the certificate of analysis (COA).

Are PT-141 and bremelanotide the same compound?

Yes, they are synonyms for the same cyclic heptapeptide, identified by PubChem CID 9941379 and CAS 189691-06-3.

How should the compound be stored?

At -20 °C, protected from light and moisture, as a lyophilized powder until reconstitution.

Does the certificate of analysis come with the lot?

Yes, every lot has a matching COA that can be verified before purchase using the button on this page.

Who can purchase PT-141?

Sales are restricted to qualified researchers and institutions, for laboratory use only, as detailed in the research-use-only notice on this page.

See the peptide reference guide, the page on how every lot is tested by HPLC and COA and the molecular structure in the PubChem database.

Research use only (RUO). This material is supplied for in vitro laboratory research only. It is not a drug, dietary supplement or cosmetic, and it is not intended for human or veterinary use, or for the diagnosis or treatment of any condition. Sales are restricted to researchers and institutions.