ARA-290 10 mg

ARA-290 for research: identity and specifications

ARA-290 (cibinetide, also written ARA290 or pHBSP) is an 11-amino-acid synthetic peptide derived from the helix B domain of erythropoietin (CAS 1208243-50-8), made by solid-phase peptide synthesis and purified by HPLC. Supplied as a 10 mg vial, lyophilized powder, with no fillers, carriers or excipients, at ≥98% purity by HPLC and the lot-specific value reported on the certificate of analysis.

Scientific background

In preclinical literature, ARA-290 is investigated for its interaction with the innate repair receptor, a receptor complex distinct from the classical erythropoietin receptor (described as a heteromer of the erythropoietin receptor and the β common receptor, CD131). Because the peptide lacks the erythropoietic activity of the parent molecule, it is used to separate tissue-protective signaling from hematopoietic effects in experimental systems.

Cell-based assays and rodent models use ARA-290 to study neuronal and inflammatory signaling pathways, always under controlled bench conditions and without extrapolating results to human or veterinary use.

• Innate repair receptor signaling in cell models
• Models of neuropathic pain and neuronal protection in preclinical research
• Comparative studies of inflammatory pathways without hematopoietic effect
• Structure-activity work on erythropoietin-derived peptides

Technical specifications

Analytical quality and chain of custody

Every lot of ARA-290 is synthesized in registered facilities, with independent analytical verification by third-party laboratories and full chain-of-custody documentation. The certificate of analysis (COA) for each lot can be reviewed before purchase, recording HPLC purity and the other quality-control parameters used to release the material.

Reconstitution and laboratory handling

As a bench procedure, the lyophilized vial is reconstituted with a known volume of a suitable solvent, added along the inner wall of the vial, followed by gentle swirling until fully dissolved, without vigorous shaking. The reconstituted solution should be kept refrigerated and protected from light, and used in controlled assays within the stability period validated by the laboratory. Handling must be performed only by qualified personnel, in a bench environment suitable for in vitro experimentation, with lot number and storage conditions documented according to good laboratory practice.

Frequently asked questions

What is the purity of the ARA-290 supplied?

≥98% by HPLC, with the lot-specific value reported on the certificate of analysis (COA).

Are ARA-290, cibinetide and pHBSP the same compound?

Yes, these are synonyms for the same 11-amino-acid erythropoietin-derived peptide, identified by PubChem CID 91810664 and CAS 1208243-50-8.

How should the compound be stored?

At -20 °C, protected from light and moisture, as a lyophilized powder until reconstitution.

Does the certificate of analysis come with the lot?

Yes, every lot has a matching COA that can be verified before purchase using the button on this page.

Who can purchase ARA-290?

Sales are restricted to qualified researchers and institutions, for laboratory use only, as detailed in the research-use-only notice on this page.

See the peptide reference guide, the page on how every lot is tested by HPLC and COA, and the molecular structure in the PubChem database.

Research use only (RUO). This material is supplied for in vitro laboratory research only. It is not a drug, dietary supplement or cosmetic, and it is not intended for human or veterinary use, or for the diagnosis or treatment of any condition. Sales are restricted to researchers and institutions.