DSIP 5 mg

DSIP for research: identity and specifications

DSIP (Delta Sleep-Inducing Peptide, emideltide; CAS 62568-57-4) is a synthetic nonapeptide with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, originally isolated from the cerebral venous blood of sleeping rabbits. Supplied as a 5 mg vial of lyophilized powder, with no fillers, carriers or excipients, made by solid-phase peptide synthesis and purified by HPLC, at ≥98% purity with the lot-specific value reported on the certificate of analysis.

Scientific background

In experimental models, DSIP is investigated for the delta-wave electroencephalographic activity associated with sleep states, for NMDA receptor-related neuromodulation and for the dynamics of the hypothalamic-pituitary-adrenal (HPA) axis.

These findings describe observations in experimental models, obtained under controlled bench and laboratory conditions, with no inference of effect in humans or animals.

• Delta-wave EEG activity in sleep models
• NMDA receptor-related neuromodulation
• Hypothalamic-pituitary-adrenal axis dynamics in experimental models
• Comparison with other neuroactive peptides in sleep-regulation assays

Technical specifications

Analytical quality and chain of custody

Every lot of DSIP is synthesized in registered facilities, with independent analytical verification by third-party laboratories and full chain-of-custody documentation. The certificate of analysis (COA) for each lot can be reviewed before purchase, recording HPLC purity and the other quality-control parameters used to release the material.

Reconstitution and laboratory handling

As a bench procedure, the lyophilized vial is reconstituted with a known volume of a suitable solvent, added along the inner wall of the vial, followed by gentle swirling until fully dissolved, without vigorous shaking. The reconstituted solution should be kept refrigerated and protected from light, and used in controlled assays within the stability period validated by the laboratory. Handling must be performed only by qualified personnel, in a bench environment suitable for in vitro experimentation, with lot number and storage conditions documented according to good laboratory practice.

Frequently asked questions

What is the purity of the DSIP supplied?

≥98% by HPLC, with the lot-specific value reported on the certificate of analysis (COA).

What is the amino acid sequence of DSIP?

Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE), a nonapeptide also catalogued as emideltide and identified by PubChem CID 68816 and CAS 62568-57-4.

How should the compound be stored?

At -20 °C, protected from light and moisture, as a lyophilized powder until reconstitution.

Does the certificate of analysis come with the lot?

Yes, every lot has a matching COA that can be verified before purchase using the button on this page.

Who can purchase DSIP?

Sales are restricted to qualified researchers and institutions, for laboratory use only, as detailed in the research-use-only notice on this page.

See the peptide reference guide, the page on how every lot is tested by HPLC and COA and the molecular structure in the PubChem database.

Research use only (RUO). This material is supplied for in vitro laboratory research only. It is not a drug, dietary supplement or cosmetic, and it is not intended for human or veterinary use, or for the diagnosis or treatment of any condition. Sales are restricted to researchers and institutions.