Humanin 10 mg

Humanin for research: identity and specifications

Humanin is a 24-amino-acid mitochondria-derived peptide encoded within the 16S rRNA gene region of the mitochondrial genome (CAS 330936-69-1). Produced by solid-phase synthesis and purified by HPLC, it is supplied as a 10 mg vial, lyophilized powder, with no fillers, carriers or excipients, at ≥98% purity by HPLC and the lot-specific value reported on the certificate of analysis.

Scientific background

In laboratory research, humanin is studied for its role in cytoprotective signaling and in the response to mitochondrial stress, including interactions with the JAK/STAT pathway and with proteins of the BCL-2 family that regulate apoptosis in cell models.

The preclinical literature uses humanin as a reference mitochondria-derived peptide in cell culture and rodent studies of cellular stress and mitochondrial function, always under controlled bench conditions and without extrapolating results to human or veterinary use.

• Cytoprotective signaling and mitochondrial stress response in cell culture
• Interactions with JAK/STAT signaling and BCL-2 family proteins
• Mitochondria-derived peptides as research tools
• Models of cellular longevity and mitochondrial function

Technical specifications

Analytical quality and chain of custody

Every lot of Humanin is synthesized in registered facilities, with independent analytical verification by third-party laboratories and full chain-of-custody documentation. The certificate of analysis (COA) for each lot can be reviewed before purchase, recording HPLC purity and the other quality-control parameters used to release the material.

Reconstitution and laboratory handling

As a bench procedure, the lyophilized vial is reconstituted with a known volume of a suitable solvent, added along the inner wall of the vial, followed by gentle swirling until fully dissolved, without vigorous shaking. The reconstituted solution should be kept refrigerated and protected from light, and used in controlled assays within the stability period validated by the laboratory. Handling must be performed only by qualified personnel, in a bench environment suitable for in vitro experimentation, with lot number and storage conditions documented according to good laboratory practice.

Frequently asked questions

What is the purity of the Humanin supplied?

≥98% by HPLC, with the lot-specific value reported on the certificate of analysis (COA).

Where is humanin encoded?

Humanin is encoded in the mitochondrial 16S rRNA gene region (MT-RNR2) and is identified by PubChem CID 16131438 and CAS 330936-69-1.

How should the compound be stored?

At -20 °C, protected from light and moisture, as a lyophilized powder until reconstitution.

Does the certificate of analysis come with the lot?

Yes, every lot has a matching COA that can be verified before purchase using the button on this page.

Who can purchase Humanin?

Sales are restricted to qualified researchers and institutions, for laboratory use only, as detailed in the research-use-only notice on this page.

See the peptide reference guide, the page on how every lot is tested by HPLC and COA, and the molecular structure in the PubChem database.

Research use only (RUO). This material is supplied for in vitro laboratory research only. It is not a drug, dietary supplement or cosmetic, and it is not intended for human or veterinary use, or for the diagnosis or treatment of any condition. Sales are restricted to researchers and institutions.