KPV 10 mg

KPV for research: identity and specifications

KPV (lysine-proline-valine, CAS 67727-97-3) is a synthetic tripeptide corresponding to residues 11-13 of the hormone α-MSH (α-MSH 11-13), studied in models of inflammatory signaling. Supplied as a 10 mg vial of lyophilized powder, with no fillers, carriers or excipients, at ≥98% purity by HPLC, with the lot-specific value reported on the certificate of analysis.

Scientific background

KPV corresponds to the C-terminal segment of α-MSH (alpha-melanocyte-stimulating hormone). In experimental models, it is investigated for its modulation of intracellular inflammatory pathways, including NF-κB and mitogen-activated protein kinase (MAPK) signaling, in intestinal epithelial and immune cell cultures.

Preclinical literature uses the tripeptide in rodent models of intestinal inflammation and in studies of short-peptide cellular transport, always under controlled bench conditions and without extrapolating results to human or veterinary use.

• NF-κB signaling in cultured epithelial and immune cells
• MAPK pathways in in vitro inflammatory response assays
• Cellular transport of di- and tripeptides in epithelial models
• Rodent models of intestinal inflammation

Technical specifications

Analytical quality and chain of custody

Every lot of KPV is synthesized in registered facilities, with independent analytical verification by third-party laboratories and full chain-of-custody documentation. The certificate of analysis (COA) for each lot can be reviewed before purchase, recording HPLC purity and the other quality-control parameters used to release the material.

Reconstitution and laboratory handling

As a bench procedure, the lyophilized vial is reconstituted with a known volume of a suitable solvent, added along the inner wall of the vial, followed by gentle swirling until fully dissolved, without vigorous shaking. The reconstituted solution should be kept refrigerated and protected from light, and used in controlled assays within the stability period validated by the laboratory. Handling must be performed only by qualified personnel, in a bench environment suitable for in vitro experimentation, with lot number and storage conditions documented according to good laboratory practice.

Frequently asked questions

What is the purity of the KPV supplied?

≥98% by HPLC, with the lot-specific value reported on the certificate of analysis (COA).

Are KPV, Lys-Pro-Val and α-MSH (11-13) the same compound?

Yes, they are synonyms for the same tripeptide (L-lysyl-L-prolyl-L-valine), identified by CAS number 67727-97-3 and PubChem CID 125672.

How should the compound be stored?

At -20 °C, protected from light and moisture, as a lyophilized powder until reconstitution.

Does the certificate of analysis come with the lot?

Yes, every lot has a matching COA that can be verified before purchase using the button on this page.

Who can purchase KPV?

Sales are restricted to qualified researchers and institutions, for laboratory use only, as detailed in the research-use-only notice on this page.

See the peptide reference guide, the page on how every lot is tested by HPLC and COA and the molecular structure in the PubChem database.

Research use only (RUO). This material is supplied for in vitro laboratory research only. It is not a drug, dietary supplement or cosmetic, and it is not intended for human or veterinary use, or for the diagnosis or treatment of any condition. Sales are restricted to researchers and institutions.