PEG-MGF 2 mg

PEG-MGF for research: identity and specifications

PEG-MGF (PEGylated mechano growth factor) is a synthetic peptide fragment related to the E-domain of the IGF-1Ec splice variant, conjugated to polyethylene glycol (PEG) to extend its stability in experimental systems. Supplied as a 2 mg vial of lyophilized powder, with no fillers, carriers or excipients, at ≥98% purity by HPLC, with the lot-specific value reported on the certificate of analysis.

Scientific background

Mechano growth factor (MGF) is the name given to an IGF-1 splice variant that is expressed in skeletal muscle in response to mechanical load and damage in experimental models. The synthetic E-domain peptide is used in research to examine signaling that is distinct from that of mature IGF-1, while PEGylation is applied to slow enzymatic degradation and lengthen the working life of the peptide in culture.

Preclinical literature uses MGF-derived peptides in studies of muscle satellite cell activation and proliferation, myoblast culture and tissue repair models, always under controlled bench conditions and without extrapolating results to human or veterinary use.

• Satellite cell activation and proliferation in muscle cell culture
• Myoblast signaling distinct from mature IGF-1 in vitro
• Peptide stability and PEGylation effects in experimental systems
• Muscle tissue adaptation and repair in preclinical models

Technical specifications

Analytical quality and chain of custody

Every lot of PEG-MGF is synthesized in registered facilities, with independent analytical verification by third-party laboratories and full chain-of-custody documentation. The certificate of analysis (COA) for each lot can be reviewed before purchase, recording HPLC purity and the other quality-control parameters used to release the material.

Reconstitution and laboratory handling

As a bench procedure, the lyophilized vial is reconstituted with a known volume of a suitable solvent, added along the inner wall of the vial, followed by gentle swirling until fully dissolved, without vigorous shaking. The reconstituted solution should be kept refrigerated and protected from light, and used in controlled assays within the stability period validated by the laboratory. Handling must be performed only by qualified personnel, in a bench environment suitable for in vitro experimentation, with lot number and storage conditions documented according to good laboratory practice.

Frequently asked questions

What is the purity of the PEG-MGF supplied?

≥98% by HPLC, with the lot-specific value reported on the certificate of analysis (COA).

Is PEG-MGF the same as MGF?

No. MGF refers to the unmodified E-domain peptide, while PEG-MGF carries a polyethylene glycol moiety intended to improve stability in experimental systems. Both are used strictly as research reagents.

How should the compound be stored?

At -20 °C, protected from light and moisture, as a lyophilized powder until reconstitution.

Does the certificate of analysis come with the lot?

Yes, every lot has a matching COA that can be verified before purchase using the button on this page.

Who can purchase PEG-MGF?

Sales are restricted to qualified researchers and institutions, for laboratory use only, as detailed in the research-use-only notice on this page.

See the peptide reference guide and the page on how every lot is tested by HPLC and COA.

Research use only (RUO). This material is supplied for in vitro laboratory research only. It is not a drug, dietary supplement or cosmetic, and it is not intended for human or veterinary use, or for the diagnosis or treatment of any condition. Sales are restricted to researchers and institutions.