NA-Semax Amidate Nasal Spray 10 mg

NA-Semax Amidate Nasal Spray for research: identity and specifications

NA-Semax Amidate is an N-acetylated, C-terminally amidated analog of Semax, a heptapeptide built on the ACTH(4-7) fragment with a Pro-Gly-Pro extension. This presentation is a ready-to-use atomized solution in a 10 mL metered spray bottle containing 10 mg of peptide (1 mg/mL), made by solid-phase synthesis and purified by HPLC, at ≥98% purity with the lot-specific value reported on the certificate of analysis.

Scientific background

N-terminal acetylation and C-terminal amidation are described in the literature as strategies to reduce exopeptidase degradation compared with the free-chain peptide. In experimental models, this analog is investigated for its stability, for intranasal absorption of neuropeptides in mucosal models, and for the neuroregulatory signaling derived from the ACTH fragment.

The atomized-solution format is used in bench studies of dispensing reproducibility and of absorption across epithelial barriers in in vitro and preclinical models, always under controlled conditions and without extrapolating results to human or veterinary use.

• Intranasal absorption of neuropeptides in experimental models
• Neuroregulatory signaling derived from the ACTH fragment
• BDNF expression in neuronal models
• Stability of N-acetylated and amidated Semax analogs

Technical specifications

Analytical quality and chain of custody

Every lot of NA-Semax Amidato is synthesized in registered facilities, with independent analytical verification by third-party laboratories and full chain-of-custody documentation. The certificate of analysis (COA) for each lot can be reviewed before purchase, recording HPLC purity and the other quality-control parameters used to release the material.

Reconstitution and laboratory handling

Because it is a ready-to-use solution, NA-Semax Amidate requires no reconstitution. As a bench procedure, the bottle should be kept sealed and protected from light and heat between uses, and the spray nozzle should not touch surfaces or samples, to prevent cross-contamination. The atomized dispensing system allows reproducible aliquots for bench absorption assays, which should be run within the stability period validated by the laboratory. Handling must be performed only by qualified personnel wearing personal protective equipment, in an environment suitable for in vitro experimentation, with lot number and storage conditions documented according to good laboratory practice.

Frequently asked questions

What is the purity of the NA-Semax Amidate supplied?

≥98% by HPLC, with the lot-specific value reported on the certificate of analysis (COA).

What is the difference between Semax and NA-Semax Amidate?

NA-Semax Amidate is an N-acetylated, C-terminally amidated analog of Semax (Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH₂), identified by PubChem CID 172638603. It is supplied here as a solution rather than a lyophilized powder.

How should the product be stored?

At -20 °C, protected from light, keeping the bottle sealed and away from heat between laboratory uses.

Does the certificate of analysis come with the lot?

Yes, every lot has a matching COA that can be verified before purchase using the button on this page.

Who can purchase NA-Semax Amidate?

Sales are restricted to qualified researchers and institutions, for laboratory use only, as detailed in the research-use-only notice on this page.

See the peptide reference guide, the page on how every lot is tested by HPLC and COA and the molecular structure in the PubChem database.

Research use only (RUO). This material is supplied for in vitro laboratory research only. It is not a drug, dietary supplement or cosmetic, and it is not intended for human or veterinary use, or for the diagnosis or treatment of any condition. Sales are restricted to researchers and institutions.