SS-31 10 mg

SS-31 for research: identity and specifications

SS-31 (elamipretide, also catalogued as MTP-131 or the Szeto-Schiller peptide) is a synthetic tetrapeptide with the sequence D-Arg-Dmt-Lys-Phe-NH₂, studied as a mitochondria-targeted compound. Supplied as a 10 mg vial of the acetate salt (CAS 1334953-95-5), lyophilized powder, with no fillers, carriers or excipients, at ≥97% purity by HPLC, with the lot-specific value reported on the certificate of analysis.

Scientific background

Its alternating aromatic and cationic residues allow SS-31 to cross cell membranes and concentrate in the inner mitochondrial membrane, where it interacts with cardiolipin, a phospholipid essential to the organization of the electron transport chain. In experimental models, this interaction is investigated for its effects on mitochondrial cristae stability, oxidative phosphorylation efficiency and the production of reactive oxygen species (ROS).

Preclinical literature uses SS-31 in studies of mitochondrial dysfunction in cell culture and in animal models of ischemia-reperfusion, muscle and cardiac aging, and oxidative stress, always under controlled bench conditions and without extrapolating results to human or veterinary use.

• Cardiolipin binding in the inner mitochondrial membrane
• Mitochondrial bioenergetics and respiratory chain efficiency in in vitro assays
• Reactive oxygen species production in oxidative stress models
• Mitochondrial function in experimental models of tissue aging

Technical specifications

Analytical quality and chain of custody

Every lot of SS-31 is synthesized in registered facilities, with independent analytical verification by third-party laboratories and full chain-of-custody documentation. The certificate of analysis (COA) for each lot can be reviewed before purchase, recording HPLC purity and the other quality-control parameters used to release the material.

Reconstitution and laboratory handling

As a bench procedure, the lyophilized vial is reconstituted with a known volume of a suitable solvent, added along the inner wall of the vial, followed by gentle swirling until fully dissolved, without vigorous shaking. The reconstituted solution should be kept refrigerated and protected from light, and used in controlled assays within the stability period validated by the laboratory. Handling must be performed only by qualified personnel, in a bench environment suitable for in vitro experimentation, with lot number and storage conditions documented according to good laboratory practice.

Frequently asked questions

What is the purity of the SS-31 supplied?

≥97% by HPLC, with the lot-specific value reported on the certificate of analysis (COA).

Are SS-31, elamipretide and MTP-131 the same compound?

Yes, they are synonyms for the same tetrapeptide (D-Arg-Dmt-Lys-Phe-NH₂), identified by PubChem CID 11764719. The material is supplied as the acetate salt.

How should the compound be stored?

At -20 °C, protected from light and moisture, as a lyophilized powder until reconstitution.

Does the certificate of analysis come with the lot?

Yes, every lot has a matching COA that can be verified before purchase using the button on this page.

Who can purchase SS-31?

Sales are restricted to qualified researchers and institutions, for laboratory use only, as detailed in the research-use-only notice on this page.

See the peptide reference guide, the page on how every lot is tested by HPLC and COA and the molecular structure in the PubChem database.

Research use only (RUO). This material is supplied for in vitro laboratory research only. It is not a drug, dietary supplement or cosmetic, and it is not intended for human or veterinary use, or for the diagnosis or treatment of any condition. Sales are restricted to researchers and institutions.