Bundle NAD Stack

Bundle NAD Stack for research: composition

Bundle NAD Stack is a kit of three individual vials of lyophilized powder for cellular energy research: NAD+ (1000 mg), MOTS-c (10 mg) and SS-31 (10 mg). Each component is HPLC-purified, at ≥98% purity, with its own COA for every lot.

Included compounds

NAD+ (1000 mg)

Nicotinamide adenine dinucleotide, a central coenzyme of cellular redox metabolism. In in vitro assays and rodents it is studied in mitochondrial redox reactions, sirtuins and PARP-dependent DNA repair pathways (CAS 53-84-9; PubChem CID 5892).

MOTS-c (10 mg)

Mitochondrial peptide of 16 amino acids (MRWQEMGYIFYPRKLR), encoded by a short open reading frame in the mitochondrial 12S rRNA gene. In cell cultures and rodents it is investigated for metabolic homeostasis and AMPK activation (CAS 1627580-64-6; PubChem CID 146675088).

SS-31 (10 mg)

Tetrapeptide D-Arg-Dmt-Lys-Phe-NH₂ (elamipretide), targeted to mitochondria. In experimental models it is studied for its interaction with cardiolipin in the inner mitochondrial membrane and for reactive oxygen species production (CAS 736992-21-5, free base; PubChem CID 11764719).

Research rationale for the set

The set pairs a redox coenzyme, a peptide derived from the mitochondrial genome and a tetrapeptide targeted to the inner mitochondrial membrane, covering NAD+/NADH metabolism, mitochondrial signaling and electron transport chain protection at the bench. The combination is the subject of ongoing research, with no conclusions about effects in humans.

Analytical quality and COA

Every component of Bundle NAD Stack is supplied at ≥98% purity by HPLC with a certificate of analysis (COA) for each lot, backed by independent third-party analytical verification and chain-of-custody documentation. The COA can be reviewed before purchase.

Storage and handling

Store all vials at -20 °C, protected from light and moisture, in the original sealed packaging. As a bench procedure, each lyophilized vial is reconstituted separately with a known volume of a suitable solvent, added along the inner wall and gently swirled, without vigorous shaking. Handling is restricted to qualified personnel in a laboratory setting, with the lot number recorded.

Frequently asked questions

Are the three compounds in the same vial?

No. The kit contains three individual vials, so each can be reconstituted independently in experimental models.

What is the purity and how can I check the COA?

≥98% by HPLC for each component, with the lot-specific value reported on the COA of each vial, which can be reviewed before purchase.

Who can purchase this material?

Sales are restricted to qualified researchers and institutions, for laboratory use only, as stated in the research-use-only notice on this page.

See the peptide reference guide, the page on how every lot is tested by HPLC and COA and the molecular structure of NAD+ in the PubChem database.

Research use only (RUO). This material is supplied for in vitro laboratory research only. It is not a drug, dietary supplement or cosmetic, and it is not intended for human or veterinary use, or for the diagnosis or treatment of any condition. Sales are restricted to researchers and institutions.