Melanotan II 10 mg

Melanotan II for research: identity and specifications

Melanotan II (MT-II) is a synthetic cyclic heptapeptide, an analog of α-melanocyte-stimulating hormone (α-MSH), with the sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂ (CAS 121062-08-6). Supplied as a 10 mg vial, lyophilized powder, with no fillers, carriers or excipients, at ≥98% purity by HPLC, made by SPPS and purified under analytical controls documented for every lot.

Scientific background

Cyclization through a lactam bridge between Asp and Lys, together with the norleucine and D-phenylalanine substitutions, gives Melanotan II stability against proteases and activity across several melanocortin receptor subtypes. In experimental models, the compound is used to investigate binding at MC1R through MC5R and downstream cAMP signaling in cell lines.

Preclinical literature uses it in melanocortin receptor pharmacology and in structure-activity studies of cyclic α-MSH analogs, in comparison with other agonists, always under controlled bench conditions and without extrapolating results to human or veterinary use.

• Binding to melanocortin receptors MC1R through MC5R
• cAMP signaling in cell lines
• Selectivity across melanocortin receptor subtypes
• Structure-activity relationships of cyclic α-MSH analogs

Technical specifications

Analytical quality and chain of custody

Every lot of Melanotan II is synthesized in registered facilities, with independent analytical verification by third-party laboratories and full chain-of-custody documentation. The certificate of analysis (COA) for each lot can be reviewed before purchase, recording HPLC purity and the other quality-control parameters used to release the material.

Reconstitution and laboratory handling

As a bench procedure, the lyophilized vial is reconstituted with a known volume of a suitable solvent, added along the inner wall of the vial, followed by gentle swirling until fully dissolved, without vigorous shaking. The reconstituted solution should be kept refrigerated and protected from light, and used in controlled assays within the stability period validated by the laboratory. Handling must be performed only by qualified personnel, in a bench environment suitable for in vitro experimentation, with lot number and storage conditions documented according to good laboratory practice.

Frequently asked questions

What is the purity of the Melanotan II supplied?

≥98% by HPLC, with the lot-specific value reported on the certificate of analysis (COA).

Are Melanotan II and MT-II the same compound?

Yes, they are names for the same cyclic heptapeptide, identified by PubChem CID 92432 and CAS 121062-08-6. It should not be confused with Melanotan-1, which is a distinct linear peptide.

How should the compound be stored?

At -20 °C, protected from light and moisture, as a lyophilized powder until reconstitution.

Does the certificate of analysis come with the lot?

Yes, every lot has a matching COA that can be verified before purchase using the button on this page.

Who can purchase Melanotan II?

Sales are restricted to qualified researchers and institutions, for laboratory use only, as detailed in the research-use-only notice on this page.

See the peptide reference guide, the page on how every lot is tested by HPLC and COA and the molecular structure in the PubChem database.

Research use only (RUO). This material is supplied for in vitro laboratory research only. It is not a drug, dietary supplement or cosmetic, and it is not intended for human or veterinary use, or for the diagnosis or treatment of any condition. Sales are restricted to researchers and institutions.