P-21 5 mg

P-21 for research: identity and specifications

P-21 is a synthetic hexapeptide derived from ciliary neurotrophic factor (CNTF), with the sequence Ac-Asp-Gly-Gly-Leu-Ala-Gly-NH₂, developed for laboratory evaluation of neurotrophic signaling mechanisms. Supplied as a 5 mg vial of lyophilized powder, with no fillers, carriers or excipients, made by solid-phase peptide synthesis and purified by HPLC, at ≥98% purity with the lot-specific value reported on the certificate of analysis.

Scientific background

In biochemical research settings, P-21 is used in studies examining neuronal signaling pathways that mimic ciliary neurotrophic factor (CNTF), a cytokine involved in the survival of neuronal populations, and peptide stability in controlled experimental models.

Preclinical literature describes the compound in models of neuronal survival and regeneration in cell culture and in rodents, always under controlled bench conditions and without extrapolating results to human or veterinary use.

• CNTF-mimetic neurotrophic signaling
• Models of neuronal survival and regeneration
• Peptide stability in neuroscience assays
• N-acetylated and C-amidated peptides in stability research

Technical specifications

Analytical quality and chain of custody

Every lot of P-21 is synthesized in registered facilities, with independent analytical verification by third-party laboratories and full chain-of-custody documentation. The certificate of analysis (COA) for each lot can be reviewed before purchase, recording HPLC purity and the other quality-control parameters used to release the material.

Reconstitution and laboratory handling

As a bench procedure, the lyophilized vial is reconstituted with a known volume of a suitable solvent, added along the inner wall of the vial, followed by gentle swirling until fully dissolved, without vigorous shaking. The reconstituted solution should be kept refrigerated and protected from light, and used in controlled assays within the stability period validated by the laboratory. Handling must be performed only by qualified personnel, in a bench environment suitable for in vitro experimentation, with lot number and storage conditions documented according to good laboratory practice.

Frequently asked questions

What is the purity of the P-21 supplied?

≥98% by HPLC, with the lot-specific value reported on the certificate of analysis (COA).

What is the sequence of P-21?

Ac-Asp-Gly-Gly-Leu-Ala-Gly-NH₂, an N-acetylated, C-amidated hexapeptide derived from ciliary neurotrophic factor (CNTF).

How should the compound be stored?

At -20 °C, protected from light and moisture, as a lyophilized powder until reconstitution.

Does the certificate of analysis come with the lot?

Yes, every lot has a matching COA that can be verified before purchase using the button on this page.

Who can purchase P-21?

Sales are restricted to qualified researchers and institutions, for laboratory use only, as detailed in the research-use-only notice on this page.

See the peptide reference guide, the page on how every lot is tested by HPLC and COA and a compound search in the PubChem database.

Research use only (RUO). This material is supplied for in vitro laboratory research only. It is not a drug, dietary supplement or cosmetic, and it is not intended for human or veterinary use, or for the diagnosis or treatment of any condition. Sales are restricted to researchers and institutions.