Semax 10 mg

Semax for research: identity and specifications

Semax is a synthetic heptapeptide with the sequence Met-Glu-His-Phe-Pro-Gly-Pro (CAS 80714-61-0), an analog of the ACTH(4-10) fragment of adrenocorticotropic hormone, catalogued among the Russian-origin bioregulatory peptides. Supplied as a 10 mg vial of lyophilized powder, with no fillers, carriers or excipients, made by solid-phase synthesis and purified by HPLC, at ≥98% purity with the lot-specific value reported on the certificate of analysis.

Scientific background

Structurally, Semax keeps the Met-Glu-His-Phe sequence of the ACTH(4-7) fragment and adds a Pro-Gly-Pro extension, a modification described in the literature as improving resistance to peptidases compared with the native fragment. In neuronal models and rodent assays, the compound is investigated for the neuroregulatory signaling associated with ACTH(4-10), including modulation of brain-derived neurotrophic factor (BDNF) expression and neuroprotective pathways.

Preclinical literature uses Semax in studies of neurotrophins, cellular responses to ischemic stress and comparisons with other bioregulatory peptides, always under controlled bench conditions and without extrapolating results to human or veterinary use.

• BDNF expression in neuronal models
• Neuroregulatory signaling derived from the ACTH(4-10) fragment
• Neuroprotective pathways in rodent laboratory assays
• Peptide stability against peptidases in comparative assays

Technical specifications

Analytical quality and chain of custody

Every lot of Semax is synthesized in registered facilities, with independent analytical verification by third-party laboratories and full chain-of-custody documentation. The certificate of analysis (COA) for each lot can be reviewed before purchase, recording HPLC purity and the other quality-control parameters used to release the material.

Reconstitution and laboratory handling

As a bench procedure, the lyophilized vial is reconstituted with a known volume of a suitable solvent, added along the inner wall of the vial, followed by gentle swirling until fully dissolved, without vigorous shaking. The reconstituted solution should be kept refrigerated and protected from light, and used in controlled assays within the stability period validated by the laboratory. Handling must be performed only by qualified personnel, in a bench environment suitable for in vitro experimentation, with lot number and storage conditions documented according to good laboratory practice.

Frequently asked questions

What is the purity of the Semax supplied?

≥98% by HPLC, with the lot-specific value reported on the certificate of analysis (COA).

Is Semax derived from ACTH?

Yes, it is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) built on the ACTH(4-7) fragment with a Pro-Gly-Pro extension, identified by PubChem CID 9811102 and CAS 80714-61-0.

How should the compound be stored?

At -20 °C, protected from light and moisture, as a lyophilized powder until reconstitution.

Does the certificate of analysis come with the lot?

Yes, every lot has a matching COA that can be verified before purchase using the button on this page.

Who can purchase Semax?

Sales are restricted to qualified researchers and institutions, for laboratory use only, as detailed in the research-use-only notice on this page.

See the peptide reference guide, the page on how every lot is tested by HPLC and COA and the molecular structure in the PubChem database.

Research use only (RUO). This material is supplied for in vitro laboratory research only. It is not a drug, dietary supplement or cosmetic, and it is not intended for human or veterinary use, or for the diagnosis or treatment of any condition. Sales are restricted to researchers and institutions.