Sermorelin 5 mg

Sermorelin for research: identity and specifications

Sermorelin (GRF 1-29, GHRH 1-29) is a synthetic 29-amino-acid peptide corresponding to the N-terminal fragment of growth hormone-releasing hormone (GHRH), CAS 86168-78-7. Supplied as a 5 mg vial, lyophilized powder, with no fillers, carriers or excipients, at ≥98% purity by HPLC, made by SPPS and purified under analytical controls documented for every lot.

Scientific background

The first 29 residues retain the biological activity of native GHRH, which makes sermorelin a reference tool for studying binding to the GHRH receptor in pituitary somatotroph cells. In experimental models, activation of this G protein-coupled receptor is investigated for cAMP signaling and growth hormone release in pituitary cell culture.

Preclinical literature uses sermorelin in structure-activity studies of GHRH analogs and in rodent models of the hypothalamic-pituitary somatotropic axis, always under controlled bench conditions and without extrapolating results to human or veterinary use.

• GHRH receptor binding in pituitary cells
• Downstream cAMP signaling
• Growth hormone axis in experimental models
• Structure-activity relationships of GHRH analogs

Technical specifications

Analytical quality and chain of custody

Every lot of Sermorelin is synthesized in registered facilities, with independent analytical verification by third-party laboratories and full chain-of-custody documentation. The certificate of analysis (COA) for each lot can be reviewed before purchase, recording HPLC purity and the other quality-control parameters used to release the material.

Reconstitution and laboratory handling

As a bench procedure, the lyophilized vial is reconstituted with a known volume of a suitable solvent, added along the inner wall of the vial, followed by gentle swirling until fully dissolved, without vigorous shaking. The reconstituted solution should be kept refrigerated and protected from light, and used in controlled assays within the stability period validated by the laboratory. Handling must be performed only by qualified personnel, in a bench environment suitable for in vitro experimentation, with lot number and storage conditions documented according to good laboratory practice.

Frequently asked questions

What is the purity of the Sermorelin supplied?

≥98% by HPLC, with the lot-specific value reported on the certificate of analysis (COA).

Are sermorelin, GRF 1-29 and GHRH(1-29) the same compound?

Yes, they are names for the same 29-residue peptide, identified by PubChem CID 16132413 and CAS 86168-78-7.

How should the compound be stored?

At -20 °C, protected from light and moisture, as a lyophilized powder until reconstitution.

Does the certificate of analysis come with the lot?

Yes, every lot has a matching COA that can be verified before purchase using the button on this page.

Who can purchase Sermorelin?

Sales are restricted to qualified researchers and institutions, for laboratory use only, as detailed in the research-use-only notice on this page.

See the peptide reference guide, the page on how every lot is tested by HPLC and COA and the molecular structure in the PubChem database.

Research use only (RUO). This material is supplied for in vitro laboratory research only. It is not a drug, dietary supplement or cosmetic, and it is not intended for human or veterinary use, or for the diagnosis or treatment of any condition. Sales are restricted to researchers and institutions.