Kisspeptin-10 10 mg

Kisspeptin-10 for research: identity and specifications

Kisspeptin-10 (KP-10, human metastin 45-54) is a synthetic decapeptide of sequence Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂, the shortest C-terminal fragment of kisspeptin that retains full receptor activity (CAS 374675-21-5). Supplied as a 10 mg vial, lyophilized powder, with no fillers, carriers or excipients, at ≥98% purity by HPLC and the lot-specific value reported on the certificate of analysis.

Scientific background

Kisspeptin-10 binds the KISS1 receptor (KISS1R, also known as GPR54), a G protein-coupled receptor expressed in hypothalamic neurons. In experimental models, receptor activation is investigated for downstream signaling and for the pathways that control GnRH, LH and FSH release.

The preclinical literature uses the peptide in hypothalamic cell and tissue models and in rodent studies of the reproductive (hypothalamic-pituitary-gonadal) axis, always under controlled bench conditions and without extrapolating results to human or veterinary use.

• Binding and signaling through the KISS1R (GPR54) receptor
• GnRH, LH and FSH release pathways in hypothalamic models
• G protein-coupled receptor signaling downstream of KISS1R
• Neuroendocrine regulation of the reproductive axis in rodent models

Technical specifications

Analytical quality and chain of custody

Every lot of Kisspeptin-10 is synthesized in registered facilities, with independent analytical verification by third-party laboratories and full chain-of-custody documentation. The certificate of analysis (COA) for each lot can be reviewed before purchase, recording HPLC purity and the other quality-control parameters used to release the material.

Reconstitution and laboratory handling

As a bench procedure, the lyophilized vial is reconstituted with a known volume of a suitable solvent, added along the inner wall of the vial, followed by gentle swirling until fully dissolved, without vigorous shaking. The reconstituted solution should be kept refrigerated and protected from light, and used in controlled assays within the stability period validated by the laboratory. Handling must be performed only by qualified personnel, in a bench environment suitable for in vitro experimentation, with lot number and storage conditions documented according to good laboratory practice.

Frequently asked questions

What is the purity of the Kisspeptin-10 supplied?

≥98% by HPLC, with the lot-specific value reported on the certificate of analysis (COA).

Are Kisspeptin-10, KP-10 and metastin 45-54 the same compound?

Yes, they are synonyms for the same decapeptide fragment of human kisspeptin, identified by PubChem CID 25240297 and CAS 374675-21-5.

How should the compound be stored?

At -20 °C, protected from light and moisture, as a lyophilized powder until reconstitution.

Does the certificate of analysis come with the lot?

Yes, every lot has a matching COA that can be verified before purchase using the button on this page.

Who can purchase Kisspeptin-10?

Sales are restricted to qualified researchers and institutions, for laboratory use only, as detailed in the research-use-only notice on this page.

See the peptide reference guide, the page on how every lot is tested by HPLC and COA, and the molecular structure in the PubChem database.

Research use only (RUO). This material is supplied for in vitro laboratory research only. It is not a drug, dietary supplement or cosmetic, and it is not intended for human or veterinary use, or for the diagnosis or treatment of any condition. Sales are restricted to researchers and institutions.