SNAP-8 10 mg

SNAP-8 for research: identity and specifications

SNAP-8 (acetyl octapeptide-3) is a synthetic octapeptide studied as a mimetic of the N-terminal domain of the SNAP-25 protein. Supplied as a 10 mg vial of lyophilized powder, with no fillers, carriers or excipients, at ≥98% purity by HPLC, produced by solid-phase synthesis and purified under documented analytical controls for each lot.

Scientific background

SNAP-25 is one of the SNARE proteins that drive vesicle fusion and neurotransmitter release. As a short peptide that reproduces its N-terminal region, SNAP-8 is examined in experimental systems for its role in SNARE complex assembly dynamics and in models of catecholamine and neurotransmitter release.

The preclinical literature also places SNAP-8 in in vitro dermatological research models that look at patterns of cutaneous muscle contraction signaling, always under controlled bench conditions and without extrapolating results to human or veterinary use.

• SNARE complex assembly dynamics in vitro
• Neurotransmitter and catecholamine release in cell models
• SNAP-25 N-terminal domain mimetic peptides
• Cutaneous muscle contraction signaling in research models

Technical specifications

Analytical quality and chain of custody

Every lot of SNAP-8 is synthesized in registered facilities, with independent analytical verification by third-party laboratories and full chain-of-custody documentation. The certificate of analysis (COA) for each lot can be reviewed before purchase, recording HPLC purity and the other quality-control parameters used to release the material.

Reconstitution and laboratory handling

As a bench procedure, the lyophilized vial is reconstituted with a known volume of a suitable solvent, added along the inner wall of the vial, followed by gentle swirling until fully dissolved, without vigorous shaking. The reconstituted solution should be kept refrigerated and protected from light, and used in controlled assays within the stability period validated by the laboratory. Handling must be performed only by qualified personnel, in a bench environment suitable for in vitro experimentation, with lot number and storage conditions documented according to good laboratory practice.

Frequently asked questions

What is the purity of the SNAP-8 supplied?

≥98% by HPLC, with the lot-specific value reported on the certificate of analysis (COA).

What is the difference between SNAP-8 and endogenous SNAP-25?

SNAP-25 is a large endogenous protein. SNAP-8 is an eight-amino-acid synthetic peptide that reproduces part of its N-terminal domain and is used only as a research reagent in models of SNARE complex assembly.

How should the compound be stored?

At -20 °C, protected from light and moisture, as a lyophilized powder until reconstitution.

Does the certificate of analysis come with the lot?

Yes, every lot has a matching COA that can be verified before purchase using the button on this page.

Who can purchase SNAP-8?

Sales are restricted to qualified researchers and institutions, for laboratory use only, as detailed in the research-use-only notice on this page.

See the peptide reference guide and the page on how every lot is tested by HPLC and COA.

Research use only (RUO). This material is supplied for in vitro laboratory research only. It is not a drug, dietary supplement or cosmetic, and it is not intended for human or veterinary use, or for the diagnosis or treatment of any condition. Sales are restricted to researchers and institutions.