Adipotide 5 mg

Adipotide for research: identity and specifications

Adipotide (CAS 859216-15-2) is a chimeric peptide that links an adipose-tissue vasculature homing peptide (sequence CKGGRAKDC) to a pro-apoptotic domain derived from the KLAKLAK motif. Supplied as a 5 mg vial, lyophilized powder, with no fillers, carriers or excipients, at ≥98% purity by HPLC, produced by solid-phase synthesis and purified under documented analytical controls.

Scientific background

The homing domain directs the peptide to proteins expressed on the surface of endothelial cells of the adipose-tissue vasculature, such as prohibitin, while the (KLAKLAK)2 domain disrupts mitochondrial membranes and induces apoptosis after internalization. This tissue-targeting peptide design is investigated in studies of vascular biology and cellular selectivity.

In preclinical models in rodents and non-human primates, the compound has been investigated for selective induction of apoptosis in endothelial cells of the adipose-tissue vasculature, within research on energy metabolism and cell signaling, always under controlled laboratory conditions and without extrapolating results to human or veterinary use.

• Recognition of adipose-tissue endothelial targets by homing peptides
• Apoptosis through mitochondrial membrane disruption in cell models
• Biology of the adipose-tissue vasculature in experimental models
• Structure-activity relationship of chimeric targeting peptides

Technical specifications

Analytical quality and chain of custody

Every lot of Adipotide is synthesized in registered facilities, with independent analytical verification by third-party laboratories and full chain-of-custody documentation. The certificate of analysis (COA) can be requested before purchase, recording HPLC purity and the other quality-control parameters used to release the material.

Reconstitution and laboratory handling

As a bench procedure, the lyophilized vial is reconstituted with a known volume of a suitable solvent, added along the inner wall of the vial, followed by gentle swirling until fully dissolved, without vigorous shaking. The reconstituted solution should be kept refrigerated and protected from light, and used in controlled assays within the stability period validated by the laboratory. Handling must be performed only by qualified personnel, in a bench environment suitable for in vitro experimentation, with lot number and storage conditions documented according to good laboratory practice.

Frequently asked questions

What is the purity of the Adipotide supplied?

≥98% by HPLC, with analytical information for the material available on the certificate of analysis (COA).

What characterizes Adipotide structurally?

It is a chimeric peptide combining a vascular homing domain (CKGGRAKDC) with a pro-apoptotic (KLAKLAK)2 domain, identified by PubChem CID 163360068 and formula C111H206N36O28S2.

How should the compound be stored?

At -20 °C, protected from light and moisture, as a lyophilized powder until reconstitution.

Is a certificate of analysis available?

Yes, the COA can be requested before purchase, with the purity and identity data for the material.

Who can purchase Adipotide?

Sales are restricted to qualified researchers and institutions, for laboratory use only, as detailed in the research-use-only notice on this page.

See the peptide reference guide, the page on how every lot is tested by HPLC and COA and the molecular structure in the PubChem database.

Research use only (RUO). This material is supplied for in vitro laboratory research only. It is not a drug, dietary supplement or cosmetic, and it is not intended for human or veterinary use, or for the diagnosis or treatment of any condition. Sales are restricted to researchers and institutions.